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29 Cards in this Set
- Front
- Back
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Filgrastim
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MOA: G-CSF
- stimulates neutrophil production and activity USE: - prophylaxis for chemo neutropenia - treatment for chronic neutropeni SE: - bone pain - hyper uricemia MNEMONICS - Fil(l) spaces in gras(s) - Fil(l) a neutrophil |
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Erythropoietin
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MOA:
- Endogenous analog which increases RBC production USE: - anemia due to chemo - not when anticipated outcome is cure SE: - hypertension - thrombotic events - seizure - shortened overall survival/progession in certain cancers |
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Abiraterone
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MOA:
- CYP 17a1 blockade - Decreases androgen production - Ketoconizole derivative USE: - Prostate cancer treatment SE: - “Hot flashes” common, general pain, N&V, constipation, asthenia, hypertension, hepatotoxicity, gynecomastia MNEMONIC: - A = anti-androgen - LGBA: lesbian gay bisexual alliance |
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Bicalutamide
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MOA:
- Androgen receptor inhibitor o Competitive inhibitor USE: - Prostate cancer treatment - Used in combination with GnRH agonist SE: - “Hot flashes” common, general pain, N&V, constipation, asthenia, hypertension, hepatotoxicity, gynecomastia - liver damage - diarrhea MNEMONIC: - bi – goes both ways – goes with both the GnRH inhibitors or not - LGBA: lesbian gay bisexual alliance |
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Goserelin
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MOA:
- GnRH agonist - Initial surge of LH and FSH which temporarily increases and ultimately decreases testosterone due to receptor overload USE: - Treatment of prostate cancer - Not in metastatic cancer due to spinal cord compression risk/bone fractures SE: - Antiandrogen: gynecomastia, impotence, HA, osteopenia, injection site reactions - Edema, depression, acne, rash, alopecia, N&V, weight gain, testicular atrophy/pain - Transient rise in testosterone at onset of treatment MNEMONIC: - LGBA: lesbian gay bisexual alliance |
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Leuprolide
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MOA:
- GnRH agonist - Initial surge of LH and FSH which temporarily increases and ultimately decreases testosterone due to receptor overload USE: - Treatment of prostate cancer - Not in metastatic disease due to spinal cord compression risk/bone fractures SE: - Antiandrogen: gynecomastia, impotence, HA, osteopenia, injection site reactions - Edema, depression, acne, rash, alopecia, N&V, weight gain, testicular atrophy/pain - Transient rise in testosterone at onset of treatment MNEMONIC: - pro for prostate - LGBA: lesbian gay bisexual alliance |
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Erlotenib
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MOA:
- Tyrosine kinase inihibitor - EGFR USE: - EGFR+ lung cancers (one example), gliomas - Pancreatic cancer SE: - Inducers or inhibitors of CYP3a4 - Inactivated by CYP3a4 - Tumors with EGFR mutations have a better prognosis than tumors with wild-type EGFR – never smokers and Asians - Neutropenia, severe diarrhea, rash, liver transaminase elevation, bleeding - RASH=good - Fatigue, pulmonary symptoms MNEMONICS: - E for EGFR |
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Sorafenib
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MOA:
- Tyrosine kinase inihibitor - Small molecule inhibitor of c-Raf and b-Raf; interrupts signals for angiogenesis and proliferation, VEGFR, KIT USE: - Renal Cell Carcinoma - Hepatocellular Carcinoma SE: - Inducers or inhibitors of CYP3a4 - Bleeding, (hand-foot) or facial skin rash, hypertensive disorder (monitor BP) - Decreased L-V faction MNEMONICS: - sore heart, liver and kidneys |
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Nolitinib
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MOA:
- Tyrosine kinase inihibitor – BCR-ABL, PDGFRa and b, c-KIT USE: - GIST, CML and other myeloproliferative disorders, hyper-eosinophilic syndrome - Imitanib resistant cancer SE: - Inducers or inhibitors of CYP3a4 - Fluid retention, N&V&D, increased liver enzymes, muscle cramps, myelosuppression, pulmonary edema - Nausea vomiting MNEMONICS: - NO more cancer NO |
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Imitanib
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MOA:
- Tyrosine kinase inihibitor – BCR-ABL, PDGFRa and b, c-KIT USE: - GIST, CML and other myeloproliferative disorders, hyper-eosinophilic syndrome - Develop resistance SE: - Inducers or inhibitors of CYP3a4 - Fluid retention, N&V&D, increased liver enzymes, muscle cramps, myelosuppression, pulmonary edema - Nausea vomiting MNEMONICS: - GLEEVIC |
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Panitumomab
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MOA:
- Anti- EGFR USE: - EGFR+ lung cancers (one example), gliomas - Pancreatic cancer - Check KRAS mutation SE: - Inducers or inhibitors of CYP3a4 - Inactivated by CYP3a4 - Tumors with EGFR mutations have a better prognosis than tumors with wild-type EGFR – never smokers and Asians - Neutropenia, severe diarrhea, rash, liver transaminase elevation, bleeding - RASH=good - Fatigue, pulmonary symptoms MNEMONICS: - NO more cancer NO |
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Cetuximab
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MOA:
- Anti- EGFR USE: - EGFR+ lung cancers (one example), gliomas - Pancreatic cancer - Metastatic colorectal cancer, squamous cell carcinomas of the head and neck - Check KRAS SE: - Inducers or inhibitors of CYP3a4 - Inactivated by CYP3a4 - Tumors with EGFR mutations have a better prognosis than tumors with wild-type EGFR – never smokers and Asians - Neutropenia, severe diarrhea, rash, liver transaminase elevation, bleeding - RASH=good - Fatigue, pulmonary symptoms MNEMONICS: - NO more cancer NO |
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Bevacizumab
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MOA:
- VEGF (ligand) antibody USE: - Breast cancer, renal cell carcinoma, GBM, hepatocellular carcinoma, adjuvant therapy to colon cancer SE: - Wound healing (stop 6 wks before and after surgery) - Bleeding, GI perforation, thrombosis MNEMONICS: - Be - vascular |
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Trastuzumab
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MOA:
- Anti-Her2 USE: - Breast cancer o Metastatic her2+ o adjuvent SE: - CHF, diarrhea, fevers, chills hypersensitivity MNEMONICS: - Remember breast – no real reason - Tu- Her2 |
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Rituximab
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MOA:
- Anti-CD20 (B-cell lymphocytes) causing apoptosis, opsinization, and cell lysis USE: - CD20+ lymphomas, CLL, NHL, DLBCL, ITP - NOT HODGKINS SE: - Fatal infusion reaction (thrombocytopenia), grade 3/4 cytopenia, mucocutaneous reactions , Hep B reactivation with fulminant hepatitis, tumor lysis syndrome with severe renal toxicity, cardiac dysrhythmias MNEMONICS: - Ri = do things twice = CD20 |
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Lenalidomide
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MOA:
- Antiangiogenic properties – mechanism of action unknown; effect on cytokines? - Immunomodulators – decreases proinflamm and increases antiinflamm cytokines USE: - multiple myeloma SE: - Teratogenic, ↑DVT and PE risk, myelosuppression MNEMONICS: - Sounds like thalidomide |
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Bortezimib
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MOA:
- Reversible proteasome inhibitor of ubiquitin pathway – prevent degredation of proapoptotic proteins; cytotoxic USE: - multiple myeloma SE: - GI effects, weakness, fever, thrombocytopenia, neutropenia, anemia, cardiac effects, etc. MNEMONICS: - ABORT - antiapoptosis |
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Irinotecan
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MOA:
- Inhibitor of topoisomerase I - Stuck in G2 USE: - Colon cancer, lung, ovarian - Metabolized to active form by UGT1 (must be active) o Also overdose - Bile elimination SE: - DIARRHEA, myelosuppression - CYP3a4 inihibitor or inducer – can inhibit it MNEMONICS: - Tecan = pecan = on the TOP of 1 pie - I = 1 |
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Doxorubicin
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MOA:
- Anthracycline antibiotic, intercalates into DNA, free radical formation USE: - Leukemias and Hodgkin’s Lymphoma, breast cancer, ovarian cancer, thyroid cancer, and soft tissue sarcoma, Kaposi’s Sarcoma SE: - -can turn patient’s secretions red - **Cumulative cardiac toxicity → dilated cardiomyopathy and CHF - alopecia - cyclosporine and pacitaxol inhibit clearance MNEMONICS: - Rubi = ruby = red |
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Oxaliplatin
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MOA:
- Alkylating agent - A Causes intra-strand cross-linking of guanine nucleotides, creating bends in the DNA strand and inhibiting DNA replication USE: - Testicular, sarcomas, ovarian cancer, small cell lung cancer, germ cell tumors SE: - No renal toxicity! - Dose limiting neuropathy - irreversible - Doesn’t cause alopecia MNEMONICS: - oxen are hairy = no alopecia and live in cold areas = cold sensitivity |
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Carboplatin
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MOA:
- A Causes intra-strand cross-linking of guanine nucleotides, creating bends in the DNA strand and inhibiting DNA replication USE: - Testicular, Sarcomas, ovarian cancer, small cell lung cancer, germ cell tumors +++ - Calvert formula for dosing – target AUC + GF*25 SE: - Renal toxicity - Mg + wasitng MNEMONICS: - carbo load before marathon = longer half life |
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Cisplatin
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MOA:
- A Causes intra-strand cross-linking of guanine nucleotides, creating bends in the DNA strand and inhibiting DNA replication USE: - Testicular, sarcomas, ovarian cancer, small cell lung cancer, germ cell tumors ++ - Shorter half life SE: - Renal toxicity - Ototoxicity - Mg+ wasting MNEMONICS: - Cister = sister= hearing problems |
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Vincristine
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MOA:
- Inhibits microtubule formation by binding microtubules o M-phase specific USE: - Hodgkin’s Lymphoma and ALL SE: - Neurotoxicity (areflexia, peripheral neuritis), paralytic ileus, myelosuppression, vesicant - cardiac MNEMONICS: - vin = vine = microtubule |
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Fludarabine
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MOA:
- purine analog = ihbitis DNA synthase USE: - unknown SE: - pulmonary toxicity - “AIDS in a bottle” MNEMONICS: - pulm tox = like Flu |
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5-flourouracil
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MOA:
- Act on S phase of cell cycle (DNA synthesis); pyrimidine analog that complexes folic acid, inhibits thymidylate, blocking thymidine nucleotide synthesis - DPD inactivated = mutation = lethal toxicity USE: - Solid tumors SE: - Administered with leucovorin, a vitamin that increases 5-FU uptake - Myelosuppression with thymididine - Photosensitivity - Cerebellar toxicity MNEMONICS: - FU thymidylate synthase |
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Cytosine arabinoside (cytarabine)
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MOA:
- Inhibits DNA polymerase USE: - Leukemias, lymphomas SE: - Conjunctivitis, chest pain, CNS MNEMONICS: - C = side effects |
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Methotrexate
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MOA:
- Anti-metabolite – inhibitor of dihydrofolate reductase, an enzyme in the thymidine synthetic pathway - S phase – folic acid analog - NSAIDs decrease excretion USE: - ALL - intrathecally SE: - Myelosuppression, reversible with leucovorin (folinic acid) “rescue”. Teratogenic. Mucositis, macrovesicular fatty liver MNEMONICS: - folATE - methotrexATE |
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Chlorambucil
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- CLL, PCV, NHL
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Cyclophosphamide
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MOA:
- Alkylates guanine nucleotides; formation of DNA cross-links - CYP450 inactivated USE: - Hematogenous cancers, autoimmune disorders SE: - Carcinogentic - Hematuria – IFOS - Cystitis – Mesna prophyl - Pulmondary - SIADH - CNS - Cardiac MNEMONICS: - Cyclops – carcinogenics, hates reflection so much so he starts attacking himself (autoimmune) |
