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39 Cards in this Set
- Front
- Back
Schnabels Cavernous optic Atrophy
1. associations 2. path/special stain |
associated with glaucoma or vascular occlusive disorders
Cavernous spaces with hyaluronic acid Hyaluronic acid stains + with acid mucopolysaccharides (colloidal iron) |
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Medulloepithelioma
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aka diktyoma
neoplasm of the ciliary body (nonpig epithelium) Unilateral prior to 6y/o can be simple or teratoid, benign or malignant rarely metastisizes, local resection. |
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Histiocytosis X
1. synonym 2. special stains 3. path finding 4. associated syndromes |
Aka Langerhans cell hystiocytosis
stains +S-100 & vimentin Path has Birbeck granules includes: Eosiphilic granuloma of the bone, Hand-Schüller-Christian disease & Letterer-Siwe disease |
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fibrous and osseous metaplasia occurs in what disorder and which cell layer
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Phthisical eyes
RPE |
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Choroidal hemangiomas have what kind of growth pattern
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localized and diffuse (Sturge-Weber)
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Identify the layers involved with Typical Peripheral Cystoid Degeneration and Reticular Cystoid Degeneration
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TPCD: Outer plexiform layer
RCD: Nerve fiber layer |
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Goblet cells are most easily identified with which stain
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PAS (periodic acid-Schiff)
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Oncocytoma
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benign neoplasm of the caruncle.
Electron Micro shows cytoplasm packed with mitochondria |
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JXG
1. common systemic finding 2. age of presentation of ocular findings 3. Ocular findings 4. histologic features |
1. raised orange skin leasions
2. under 6mo 3. hyphema, glaucoma 4. granuloma with Touton Giant cells |
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Granulomatous reaction to Descemet's membrane is associated with what organisms?
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HSV, HZV
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Order of prevelent location for BCC
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lower lid, medial canthus, upper lid, lateral canthus
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Fungal keratitis:
Yeast or mold? |
mold. Candida and crypto are yeast
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Do the following represent local or systemic disease:
1. Conjunctival amyloid 2. Subcutaneous amyloid |
1. Local disease
2. Systemic disease |
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Conjunctival melanomas
1. what portion occurs from PAM 2. Mortality rate 3. Location of mets 4. poor prognostic indicators |
1. 2/3
2. 25% 3. local LN's 4. pagetoid spread, >0.75mm depth, orbit/scleral invasion, eyelid margin involvement |
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Causes of interstitial keratitis
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conj. syphilis, HSV, HZV, leprosy, lyme, TB, onchocerciasis, sarcoid
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Which part of the eye is most sensitive to rad Tx
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Lens>cornea>retina>ON
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% of patients that have xanthalasma that have dyslipidemia?
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33%
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1. Typical inheritance pattern of phakomatoses?
2. Exceptions to the rule? |
1. AD
2. Sturge-Weber & Wyburn Mason sporadic (capital W), Ataxia-telandiectasia AR |
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With acute elevation in IOP where is the edema in otherwise normal corneas?
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Epithelium
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Nevus of Ota increases the risk of what?
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UVEAL melanoma in CAUCASIANS
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Are Russell's bodies and Dutcher's bodies an indication of malignant or benign lesion?
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benign/reactive
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If a patient has recurrent or recalcitrant vitritis, what should be considered?
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lymphoma
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1. Elastosis stains what color with H&E?
2. what is it caused by? |
1. basophilic (blue)
2. UV damage |
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Identify where the lesion is:
1. essential blepharospasm 2. hemifacial spasm 3. facial myokymia |
1. basal ganglia
2. compression (abnl vessels -90% > tumors) of the 7th CN within the cerebellopontine angle 3. Pons (CN or fascicle) MS adults, glioma children |
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1. Sudden appearance of multiple seborrheic keratoses suggests what Dx?
2. Further w/u? |
1. Leser-Trelat sign - GI malignancy
2. w/u for GI malignancy |
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Describe the melanocytes in nevi
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"nevus cells" as apposed to their normal appearance, nevus cells are rounder, more abundant eosinophilic cytoplasm
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To preserve crystals in cystinosis process should be with what?
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Absolute alcohol
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What is the best way to clinically detect Kayser-Fleisher rings?
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gonioscopy - detectable in the most peripheral descemet's membrane
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Most important prognostic indication of systemic involvement in ocular/orbital lymphoma?
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Location: Eyelid > orbital > conjunctival
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Which rosettes are most specific for RB
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Flexner-Wintersteiner
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1. Foamy cells =?
2. Name two concerning syndromes |
1. Xanthalasma - engorged macrophages
2. Necrobiotic xanthogranuloma - may be associated with MM (get electrophoresis - Erdheim-Chester disease - recurrent nodular xanth with multi organ involvment |
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Difference between dermoid cyst and EIC?
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EIC does not have appendages (hair, sweat glands, etc.)
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dual cuboidal cell layer =?
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sweat gland
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"blue and below"
clefting artifact lobules with peripheral pallisades |
BCC
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Path prep for sebacious cell CA?
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full thickness Bx, frozen section with oil red O, map Bx's
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"purple swiss cheese"
significant Sx |
Adenocystic CA
pain due to nerve irritation |
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Psamoma bodies
whorls |
meningioma
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large endothelial lined vessels with large fibrous septa and lymphoid aggregates with germinal centers.
1. Dx 2. typical age? |
1. orbital lymphangioma
2. Childhood <10 |
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What are features that help to distinguish between IOI and lymphoproliferative disorders
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hypocellularity and prominent fibrovascular stroma - both seen in IOI
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