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26 Cards in this Set
- Front
- Back
- 3rd side (hint)
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For a drug to produce an effect in the CNS, a drug must pass barriers namely the tissues that comprise the ____, the walls of the ____ that ____, and the ____ |
Wall of the intestine Capillaries Perfuse the gut Blood brain barrier |
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These are the walls of the capillaries that perfuses the brain |
Blood brain barrier |
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The filtering mechanism of capillaries of brain and spinal cord |
BBB |
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5 factors affecting drug Distribution |
Blood flow Capillary permeability Protein binding Drug-Drug interaction Depot binding |
BCPDD |
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Relationship of blood flow and Distribution |
Higher blood perfusion&cardiac output = higher distribution |
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Relationship of capillary permeability and distribution |
Higher CP = higher distribution |
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It is the capacity of the blood vessel wall to allow for the flow of small molecules in and out of the blood vessel |
Capillary permeability |
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Once the drug enters the systemic circulation, it may: (2) |
Stay in solution Bound to serum proteins |
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Drugs that bound to albumin |
Acidic drugs Neutral drugs |
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4 acidic drugs |
Phenytoin Warfarin Tolbutamide Phenobarbital |
PWTP |
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5 basic drugs |
Lidocaine Quinidine Propranolol Chlorpromazine Pentazocin |
LQPCP |
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Brand name and use of phenytoin |
Dilantin Anticonvulsant |
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Brand name and use of warfarin |
Coumadin Anticoagulant |
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Brand name and use of tolbutamide |
Orinase Antidiabetic |
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Use of phenobarbital |
Anticonvulsant |
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Brand name and use of lidociane |
Lidopen Local anesthetic |
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Brand name and use of quinidine |
Quinaglute Antimalarial |
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Brand name and use of propranolol |
Inderal Antidisrhythmic |
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Brand name and use of chlorpromazine |
Thorazine Antipsychotic |
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Brand name and use of pentazocin |
Talwin Analgesic |
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Serum proteins that is usual carrier of basic drugs |
Alpha 1 glycoprotein |
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If a drug molecule detached from the protein, it is then called ____ which is pharmacologically active |
Free/unbound drug |
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Drugs can also be stores in depot sites or tissue depots or ____ such as ____,____,____ |
Silent receptors Fat Muscle Bones |
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____ fat constitutes some ____ of body weight and constitutes a depot of considerable importance |
Neutral 20%-50% |
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Generic name of Depo-Provera |
Medroxyprogesterone acetate |
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Dose of depo provers |
150mg every 3 months |
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