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38 Cards in this Set
- Front
- Back
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Which of the following should increase the abuse potential of a drug?
A. Snorting it rather than injecting it intravenously B. If it can decrease basal levels of dopamine in mesolimbic pathways C. If it can decrease stimulated levels of dopamine in mesolimbic pathways D. If it can decrease prefrontal cortex inhibition of nucleus accumbens E. All of the above |
D. If it can decrease prefrontal cortex inhibition of nucleus accumbens
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thanol can interact with all of the following agents, both pharmacokinetically and pharmacodynamically. Which of the following agents increases blood levels of acetaldehyde when taken in the presence of ethanol?
A. Tolbutamide B. Penicillin C. Acetominophen D. Propoxyphene E. All of the above |
A. Tolbutamide
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Which of the following is (are) thought to occur after long-term high dose ethanol use?
A. The alcohol‑induced enhancement of GABA-A receptor function is increased. B. The activity of some hepatic metabolic enzymes is decreased. C. The activity of acetaldehyde dehydrogenase decreases. D. Cell membrane phospholipids change to make the membrane more fluid than normal. E. None of the above |
C. The activity of acetaldehyde dehydrogenase decreases.
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A slender female classmate of yours has imbibed two beers in about 45 minutes resulting in a blood alcohol level of 60 mg%. Which of the following statements are true?
A. She has significantly decreased GABAA receptor function in her brain. B. She has significantly fluidized the membranes of her neurons. C. She has significantly increased NMDA receptor function in her brain. D. She has significantly inhibited voltage-dependent calcium channels in her brain. E. None of the above |
E. None of the above
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Which of the following drugs develop a markedly narrower therapeutic index with repeated use?
a. Chloral hydrate b. Pentobarbital c. Ethanol d. Secobarbital e. All of the above |
e. All of the above
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Which of the following drugs can inhibit glutamate receptor activation?
a. Ethanol b. Pentobarbital c. Dextromethorphan d. Ketamine e. All of the above |
e. All of the above
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Which of the following drugs directly stimulate dopamine neuronal firing in the mesolimbic pathway?
a. Ethanol b. Heroin c. Cocaine d. Nicotine e. All of the above |
d. Nicotine
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Ethanol can interact with all of the following agents, both pharmacokinetically and pharmacodynamically. Which of the following agents has decreased therapeutic actions when taken in the presence of ethanol?
a. Alprazolam b. Acetominophen c. Penicillin d. Propoxyphene e. All the above |
c. Penicillin
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Which of the following is (are) thought to occur after long-term high dose ethanol use?
a. The alcohol‑induced inhibition of GABAA receptor function is decreased. b. The activity of some hepatic metabolic enzymes is decreased. c. The activity of alcohol dehydrogenase increases. d. The activity of acetaldehyde dehydrogenase increases. e. All the above |
c. The activity of alcohol dehydrogenase increases.
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A slender female classmate of yours has imbibed two beers in about 45 minutes resulting in a blood alcohol level of 60 mg%. Which of the following statements are true?
a. She has significantly decreased GABAA receptor function in her brain. b. She has significantly fluidized the membranes of her neurons. c. She has significantly decreased NMDA receptor function in her brain. d. She has significantly inhibited voltage-dependent calcium channels in her brain. e. All of the above |
c. She has significantly decreased NMDA receptor function in her brain.
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Which of the following drugs develop a markedly narrower therapeutic index with repeated use?
A. Ramelteon B. Diazepam C. Ethanol D. Oxycodone E. All of the above |
C. Ethanol
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Ethanol can interact with all of the following agents, both pharmacokinetically and pharmacodynamically. Which of the following agents has decreased therapeutic actions when taken in the presence of ethanol?
A. Alprazolam B. Penicillin C. Acetominophen D. Propoxyphene E. All the above |
B. Penicillin
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Which of the following is (are) thought to occur after long-term high dose ethanol use?
A. The alcohol‑induced enhancement of GABAA receptor function is increased. B. The activity of some hepatic metabolic enzymes is increased. C. The activity of alcohol dehydrogenase decreases. D. Cell membrane phospholipids change to make the membrane more fluid than normal. E. All the above |
B. The activity of some hepatic metabolic enzymes is increased.
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A slender female classmate of yours has imbibed two beers in about 45 minutes resulting in a blood alcohol level of 60 mg%. Which of the following statements are true?
A. She has significantly increased GABAA receptor function in her brain. B. She has significantly fluidized the membranes of her neurons. C. She has significantly increased NMDA receptor function in her brain. D. She has significantly inhibited voltage-dependent calcium channels in her brain. E. All of the above |
A. She has significantly increased GABAA receptor function in her brain.
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Which of the following agents will induce the activity of CYP3A4 when used daily for two weeks?
A. Ethanol. B. Meperidine C. Pentobarbital D. Chlordiazepoxide E. All of the above are correct F. Only A and C are true. |
F. Only A and C are true.
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Which of the following agents will be affected by induction of the activity of CYP3A4 caused by chronic ethanol use?
A. Chlordiazepoxide. B. Testosterone C. Pentobarbital D. Fluvoxamine E. All of the above are correct F. Only A and C are true. |
E. All of the above are correct
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Which of the following drugs develop a markedly narrower therapeutic index with repeated use?
A. Secobarbital. B. Alprazolam C. Ethanol D. Meperidine E. All of the above are correct F. Only A and C are true. |
F. Only A and C are true.
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Which of the following drugs can inhibit glutamate receptor activation?
A. Ethanol B. Ketamine C. Pentobarbital D. Dextromethorphan E. All of the above correct F. Only A and C are true. |
E. All of the above correct
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Repeated use of which of the following sedatives is most likely to affect GABA-A receptor subunit composition?
A. Ethanol B. Zolpidem C. Pentobarbital D. Morphine E. All of the above are correct F. Only A and C are true. |
F. Only A and C are true.
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Which of the following treatments for alcoholics may help decrease anxiety occurring during withdrawal from alcoholism?
A. Odansetron B. Propranolol C. Naltrexone D. Disulfiram E. All of the above are correct F. Only A and C are true. |
A. Odansetron
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Which of the following drugs directly stimulate dopamine neuronal firing in the mesolimbic pathway?
A. Amphetamine B. Nicotine C. Ethanol D. Butorphanol E. All of the above are correct F. Only A and C are true. |
B. Nicotine
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Which of the following drugs can potently (at low doses) increase dopamine euronal transmission in the mesolimbic pathway but by an unknown echanism of action?
A. Ethanol B. Diazepam C. Amylbarbital D. Gamma hydroxybutyrate E. All of the above are correct F. Only A and C are true. |
F. Only A and C are true.
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Which of the following drugs is most likely to cause up-regulation of glutamate receptors after chronic repeated use?
A. Oxycodone B. Clonazepam C. Gamma hydroxybutyrate D. Ethanol E. All of the above are correct F. Only A and C are true. |
D. Ethanol
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The first noticeable signs of intoxication occur at this blood alcohol level in most non-alcoholic people
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
A. 20-25 mg/dl
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This blood alcohol level is considered legally impaired in most states.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
B. 50 mg /dl
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This blood alcohol level is considered legally impaired for persons under the age of 21 in Florida.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
A. 20-25 mg/dl
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This blood alcohol level results in deep sedation or coma in non-tolerant people.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
E. 250-400 mg/dl
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This blood alcohol level is anxiolytic and may cause disinhibition of behavior in non-tolerant people.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
A. 20-25 mg/dl
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This blood alcohol level is seven times more likely to cause an accident if driving a car.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
C. 100 mg/dl
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This blood alcohol level is 25 times more likely to cause an accident when driving a car.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
D. 130-150 mg/dl
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The lowest blood alcohol level that will significantly enhance the function of GABAA receptors comprised of alpha, beta and delta subunits.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
A. 20-25 mg/dl
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The lowest alcohol level that will significantly enhance the function of GABAA receptors comprised of alpha, beta and gamma-2 subunits.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
D. 130-150 mg/dl
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A blood alcohol level that will significantly fluidize most of the plasma membranes of your neurons.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
F. 500 mg/dl
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The lowest blood alcohol level that will significantly decrease NMDA receptor function in your brain.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
B. 50 mg /dl
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The lowest blood alcohol level that will significantly inhibit voltage-dependent calcium channels in your brain.
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
C. 100 mg/dl
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The lowest blood alcohol level that will increase your chances of giving birth to a child with alcohol related neurodevelopmental disorder if you were four weeks pregnant at the time
A. 20-25 mg/dl B. 50 mg /dl C. 100 mg/dl D. 130-150 mg/dl E. 250-400 mg/dl F. 500 mg/dl |
A. 20-25 mg/dl
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Which of the following is (are) thought to occur after long-term high dose ethanol use?
A. The activity of alcohol dehydrogenase increases. B. Phospholipids in the cell membrane change to make the membrane more rigid than normal. C. Benzodiazepine-induced enhancement of GABA-A receptor function is decreased. D. The activity of many hepatic metabolic enzymes is increased. E. All of the above F. Only A and C are true. |
E. All of the above
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Ethanol
A. Directly stimulate dopamine neuronal firing B. Increase GABA inhibition of dopamine neuronal firing C. No effect on mesolimbic dopamine activity when used alone D. Mimic increased dopamine activity by blocking dopamine transporters E. Increases dopamine neuronal transmission but mechanism unknown. F. Decrease GABA inhibition of dopamine neuronal firing G. Directly inhibit dopamine neuronal firing |
E. Increases dopamine neuronal transmission but mechanism unknown.
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