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22 Cards in this Set
- Front
- Back
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Susceptible |
HBsAg -ve anti-HBc -ve anti-HBs -ve |
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Natural immunity/ past infection |
HBsAg -ve anti-HBc +ve anti-HBs +ve |
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Immune due to hepatitis B vaccination |
HBsAg -ve anti-HBc -ve anti-HBs +ve |
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Acutely infected
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HBsAg +ve
anti-HBs -ve IgM anti-HBc +ve |
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Chronically infected
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HBsAg positive
anti-HBc positive IgM anti-HBc negative anti-HBs negative |
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Interpretation unclear; four possibilities:
1. Resolved infection (most common) 2. False-positive anti-HBc, thus susceptible 3. “Low level” chronic infection 4. Resolving acute infection |
HBsAg negative
anti-HBc positive anti-HBs negative |
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Syphilis Assays |
EIA, TPPA, RPR |
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EIA +ve TPPA +ve RPR +ve (< 1 in 16) |
treponemal infection at some time
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EIA +ve TPPA +ve RPR +ve (> 1 in 16) |
recent or active treponemal infection
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EIA +ve
TPPA - ve RPR +ve |
Consistent with treponemal infection at some time/False positive
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EIA +ve
TPPA - ve RPR -ve |
Non-specific Positive (False positive)/ Early Syphilis |
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EIA -ve
TPPA - ve RPR +ve |
False postive to other organisms |
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EIA -ve
TPPA +ve RPR -ve |
False positive (require repeat) |
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EIA +ve TPPA +ve RPR -ve |
Treated Syphilis/ Early Syphilis (before 28days), Late Latent. |
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HCV antibody nonreactive
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No infection/ Early infection (need RNA testing) |
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HCV antibody reactive
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Past infection/Current infection (RNA testing) |
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HCV antibody reactive, HCV RNA detected
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Current HCV infection
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HCV antibody reactive, HCV RNA not detected
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No current HCV infection
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Hep B Treatment |
Interferon alpha 2a/b (1 year) Tenofovir |
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Hep C Treatment |
Interferon alpha + ribavarin + telaprevir |
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Hep B Treatment Indications |
HBV viral load > 2000 IU/ml (10,000 copies/ml)• Abnormal liver function tests - ALT/AST >1.5-2x upper limit of normal•
moderate inflammation/fibrosis/cirrhosis |
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Hep C treatment Indications |
acute/chronic hepatitis C
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