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10 Cards in this Set
- Front
- Back
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Physiology of Cholesterol synthesis and transport |
Steampunk station Liver Station = Import/export lipoprotein transporters Intestine Airbase = Small intestine site of absorption of FFA and cholesterol Gold Bars = Cholesterol Hot air balloon = Chylomicron Chest = Cholesterol ester for cholesterol transfer (gold inside) Tridents in hot air balloon = Chylomicron full of triglycerides E-shaped flag = Apolipoprotein A-E Lipo port lighthouse = lipoprotein lipase (LPL) gets some tridents Empty CHylomicrons enter liver at LDL receptor at apo E HMG Crude ore reducer = HMG CoA reductase = makes cholesterol Evaluator = Mevalonic acid is first intermediate VLDL ship with B anchor = HAs tridents and B shaped anchor (B100) Low density ship = lose tridents and only contain chests LDL ship uses B anchor to dock at liver High densitity Submarine = HDL from Liver collect bars Load catch platform = Lecithin (LCAT) place for placing gold into chests Chest transfer = Under LDL has chest sent to liver from Load catch
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Statins |
Steam punk pirates Knock over crude ore reducer = inhibit HMG CoA reductase Statin punk = Threatens workers to pull in LDL causing increased LDL receptor expression on hepatocytes, clearing LDLs from circulation Sinking LDL ship = Lowers LDL levels Punk kicking trident = Lowers truglycerides mildly Raised submarine = Slight increased HDL levels Gold bar plundered = Hypercholesterolemia is treated (first line) Angel = Improves chances of survival in Cardiovascular events (MOST EFFECTIVE) Crown = Coronary vasodilation Broken heart strings = statin therapy helps in MI events Pirate eating candy = Helps lower MI chance in Diabetics Clack paint stroke = Statins help stroke patients Chrome Tank = Metabolized by cytomcome P450 (expect pravastin) |
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Statin side effects |
Tarantula painted = ARe teratogenic Bite of Crispy chicken = Statins can cause elevated CK (myopathy) in weeks-months Raised LFT flag = Mild elevations in Liver function tests |
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Cholesterol and Bile |
Seagalls are bile Loading cholesterol with seagalls makes them water soluble Swept up into liver station |
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Chol-drugs |
Cho"lobster"amine fighting statin punk Prevents return of bile acids and cholesterol into liver DEcK -A = inhibits fat soluble vitamin absorbtion and statins Clamping on pipes = can causes constipation and bloating Empty gold stores = Signal to form own cholesterol activating HMG ore reducer and upregulating LDL receptors (B anchors) Cho"lobster" Scaring tridents onto VLDL = INcreases blood VLDL and triglycerides Seagall standing on stone = Can lead to gallstone formation |
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Ezetimibe |
Z-Shaped eel Blocking gold delivery at intestinal airbase from hot air balloon = blocks intestinal absorption of cholesterol by chylomicron Sinking Ship = Decreaed LDL levels Oily water = Diarrhea and constipation Raised LFT flag = increased liver function tests |
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Evolocamab |
Evoloctopus Removing pesky-9-crabs which inhibit LDL workers = PCSK9 inhibitor Increases uptake of LDL |
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Gemfibrozil (Fibratess) |
Gem Jellyfish Burning Newspaper - PPAR activated to upregulate LPL Jellyfish take down Airship and LD ship = Lower VLDL and LDL Escaping tridents = decrease serum triglycerides Lifted Submarine = Raised HDL elevated stain pirate eating crispy chicken = Statin + fibrates = myopathy and rhabdomyolysis Seegalls on rocks = gallstone chance |
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Niacin |
Loch Niacin monster Vitamin B3 Elevated submarine = Most effective at increasing HDL Nessie attacks airships, boats, tridents escape = Lowered VLDL, LDL and triglycerides Red furnace = Cutaneous Flushing and warmth Proslugger bat = increases prostaglandins Fireextinguisher = NSAID inhibits flushing Candy = Increase glucose Knitting = Hyperuricemia Raised LFT flag = increases Liver function tests. Hepatotoxicity |
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Fish Oil |
Robotic fish Sunken Trident = Lower triglycerides |
