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6 Cards in this Set
- Front
- Back
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Bleomycin |
Beluga whale Oxide bubbles = binds DNA and produces free radicals (superoxide hydroxide) Broken double helix kelp = cause single and double strand breaks in DNA Galleon = Blocks G2 phase of cell cycle Cracked crab = treats cancer |
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Bleomycin side effects |
Lung coral = causes pulmonary toxicity Hyperpigmented striae = bleomycin can cause skin toxicity Poking mouth = mucositis and stomatitis Bald beluga = alopecia |
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Anthracyclines |
Santa anthracycline Rubies = -rubicin Oxide bubles = prodcue free radicals (superoxide, hydroxide) Rubies in seaweed = intercalate in DNA --> block DNA and RNA synthesis |
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Anthracycline and actinomycin D side effects
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Dilated heart ruby sacks = cause dilated cardiomyopathy (cardiotoxicity)
Bald skull = alopecia Depleted bone chest = myelosuppression |
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Dexrazoxane |
Chelating heart sack = dexrazoxane (iron chelator) prevents the cardiotoxicity
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Actinomycin D |
Child's Doll artifact (antitumor antibiotic) Especially effective against children's tumors Artifacts in seaweed = intercalated in DNA --> blocs DNA and RNA synthesis Bald doll = alopecia |
