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195 Cards in this Set
- Front
- Back
Whats the difference btw sub and elim |
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What are the common LG and what is the trend that makes them better |
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What does and Sn1 rxn look like? |
Heat kicks out LG to make carbocat then nuc comes and attaches to make a racemic mix of enan |
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Sn1 details |
5. Uses weak nucs 6. Nuc will attack from front and back to make racemic enabled 7. Carbocat rearrangement can happen |
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What does and sn2 rxn look like? |
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Sn2 details |
7. Sn2 uses strong nucs bc nuc attacks electrophoresis in 1 step and no inter forms 8. If electrophoresis has stereocenter. And inversion must happen |
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What is the inversion for sn2 rxns |
If there are different R groups then inversion of the stereocenter happens If there are different R groups then inversion of the stereocenter happens |
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How to choose btx sn1 and 2 |
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What does the e1 expect look like? What is the RDS |
Rds=where LG leaves and Carbocat forms |
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E1 details |
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What does an E2 rxn look like? |
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E2 details |
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What DOES elimination rxn favor? |
Zaitsev product which is the most fa order substituted prod.E alkene over Z Zaitsev product which is the most fa order substituted prod.E alkene over Z |
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How to choose btw E1 and 2 |
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General view on how to choose between sn1, SN2, E1 or E2 |
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Base=E, nuc=Sn -th3 bigger the b/n=b, the smaller the b/n= n -bigger or equal to ethanol or epoxide= big |
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protic slovents |
solvents that have H atoms bonded to an oxygen, nitrogen, or sulfur. -EX: CH3OH, CH3CH2OH, acetic acid (CH3COOH), or H2O. |
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aprotic solvents |
-opposite of protic Ex: DMSO, acetone, acetonitrile and DMF. |
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-protic solvent react with, and thereby stifle? what does this mean? -
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-strong nucleophiles/bases. - solvents are bad for strong nucleophiles/bases(SN2 and E2 reactions), but are good for weak nucleophiles/bases (SN1 and E1reactions). -they do ok with E2 |
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Nuc and base |
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2 |
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Electron donators vs withdrawers and what they do |
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Ortho par vs meta reactors |
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B and E |
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B |
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A |
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D |
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