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48 Cards in this Set
- Front
- Back
MOA of finasteride (propecia)
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5-alpha-reductase inhibitor. For BPH and male-pattern baldness
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MOA of flutamide
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Nonsteroidal, competitive testosterone receptor blocker
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Clinical use of flutamide
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Prostate carcinoma
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MOA of ketoconazole
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Inhibits steroid synthesis
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MOA of spironolactone
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Inhibits steroid binding
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Side effects of finasteride
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Gynecomastia ("To prevent male-pattern baldness, give a drug that encourages female breast growth")
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These drugs are used in the treatment of PCOS to prevent hirsutism
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Ketoconazole, spironolactone
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These drugs have as their side effects gynecomastia and amenorrhea
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Ketoconazole, spironolactone
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MOA of leuprolide
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GnRH analog. Agonist when used pulsatile, antagonist when given continuously
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These are the antiandrogens
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Finasteride (5a-reductase blocker), flutamide (testosterone receptor antagonist), ketoconazole, spironolactone
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Uterine fibromas are treated with this drug
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Leuprolide
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These drugs are given to treat prostate cancer
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Flutamide, leuprolide (continuous)
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Side effects of leuprolide
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Antiandrogenic effects, n/v
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These drugs can be used to treat infertility
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Leuprolide (pulsatile), clomiphene (in PCOS)
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MOA of sildenafil
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Inhibit cGMP phosphodiesterase. Increased levels of cGMP promote corpus cavernosum smooth muscle relaxation
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MOA of vardenafil
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Inhibit cGMP phosphodiesterase. Increased levels of cGMP promote corpus cavernosum smooth muscle relaxation
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These drugs can cause impaired blue-green color vision
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Sildenafil, vardenafil
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These drugs can cause life-threatening hypotension when given with nitrates
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Sildenafil, vardenafil
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These drugs can cause headache, flushing and dyspepsia
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Sildenafil, vardenafil
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MOA of mifepristone
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Progesterone receptor blocker
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MOA of misoprostol
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PGE1 analog. Given with mifepristone to terminate pregnancy
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Side effect of mifepristone
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Heavy bleeding, GI effects (n/v, anorexia, abdominal pain)
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MOA of oral contraceptives
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Prevent estrogen surge and therefore also the LH surge; ovulation does not occur
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Side effects of OCPs
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Hypercoagulability, increased triglycerides; depression, weight gain, nausea, hypertension
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The side effects of this drug include increased triglycerides and hypercoagulability
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Oral contraceptives (synthetic progestins, estrogen)
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These drugs are protective against endometrial and ovarian cancer
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Oral contraceptives (synthetic progestins, estrogen)
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Possible side effets of HRT
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Increased risk of cardiovascular events
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Side effects of estrogen replacement therapy
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Endometrial cancer (thus they are always given with progesterone); thrombi
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MOA of dinoprostone
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PGE2 analog. Induces labor. Causes cervical dilation, uterine contraction.
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MOA of ritodrine
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Beta-2 agonist. Relaxes uterus, reduces premature uterine contractions
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MOA of terbutaline
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Beta-2 agonist. Relaxes uterus, reduces premature uterine contractions
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MOA of anastrozole
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Aromatase inhibitor. Used in post-menopausal women with breast cancer
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MOA of exemestane
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Aromatase inhibitor. Used in post-menopausal women with breast cancer
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This drug is given to induce labor
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Dinoprostone (PGE2 analog)
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These drugs are given to reduce premature uterine contractions
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Ritodrine, terbutaline
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These drugs are given in postmenopausal women with breast cancer
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Anastrozole, exemestane (aromatase inhibitors)
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This drug is given to promote recovery after burn or injury by stimulating anabolism
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Methyltestosterone
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T/F: Methyltestosterone can be used to treat breast cancer
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True. Given to treat ER-postitive breast cancer
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Side effects of methyltestosterone
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Reduces intratesticular testosterone in males by inhbiting Leydig cells. Gonadal atrophy. Increased LDL and decreased HDL.
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T/F: Giving testosterone can reduce the size of the testes
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True. Excess testosterone inhibits LH, so there is less activity in the testes
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Side effect of DES
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Clear cell adenocarcinoma of vagina in females exposed to DES in utero
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Contraindication of estrogens
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ER-postive breast cancer
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Clinical uses of estrogens (ethyinyl estradiol, DES, mestranol)
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Hypogonadism or ovarian failure; men with androgen-dependent prostate cancer
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Actions of progestins
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Reduce growth and increase vascularization of the endometrium
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Clinical uses of progestins
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Endometrial cancer, abnormal uterine bleeding, OCP
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MOA of clomiphene
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Partial agonist at hypothalamic estrogen receptors, preventing feedback inhibition and thus increasing release of LH and FSH from pituitary. Stimulates ovulation.
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This drug may cause visual disturbances
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Clomiphene
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This drug may cause multiple simultaneous pregnancies
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Clomiphene
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