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12 Cards in this Set
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Blocks transport of iodide from serum to thyroid tissue. Found in certain foods and cigarette smoke. Can be used to tx hyperthyroidism.
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Thiocynate, "jim jones effect"
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Blocks iodide transport from serum to thyroid tissues. 10x more active as cyonate. Low doses (750mg qd) are used to treat graves dz. High doses (2-3G qd) can cause fatal aplastic anemia. Also found in rocket launching pads and weed killer & fertlizer.
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Perchlorate (CLO-4)
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These drug inhibits iodine organification (the step where atomic iodine binds to tyrosine on the thryoglobulin) via inhibition of thyroxidase
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Propylthiouracil (PTU), methimazole (MMI) and carbimazole in (UK).
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This drug inhibits the orangification of iodine by inhibiting thyroperoxidase and also has perpipheral activity that inhibits 5-deiodinase that converts T4 to T3.
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Propylthuracil. MMI shares PTU central action but not this peripheral action.
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These drugs block type I and type II deiodinases to prevent conversion of T4 to T3 in periphery.
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sodium ipodate and iopanoic acid.
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The metabolism of these drugs also lead to the release of iodide which inhibits T3/T4 production. They are often used as radiology contrast dyes.
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sodium iopodate and ionpanoic acid.
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High doses of this drug cause paradoxical decrease in thyroxine biosynthesis at the organification step.
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Iodide
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This drug leads to partial descrution of the gland. It is used when prolonged treatment c/ anti-thyroid drugs or surgery has not led to remission. Disadvantage is long time before hyperthyroidism is controlled.
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Radioactive iodide. (iodotope therapeutic).
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Drugs used to treat thyroid storm are what?
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antipyretics, large dose of PTU (200-400mg) b/c of central and peripheral action. BB to counteract effects on SNS amd heart.
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This drug is used as replacement therapy if you suspect iodide deficiency.
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Iodide in small quanities (100-300ug/day).
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This drug is used to tx hypothyroidism, it is synthetic thyroxine (T4).
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Levothyroxine (synthroid)
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This drug is used to tx hypothyroidism. It is synthetic T3.
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Lyothyronine sodium (L-T3).
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