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18 Cards in this Set
- Front
- Back
Does a competitive inhibitor resemble the substrate? What about a noncompetitive inhibitor?
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Yes; No.
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Is a competitive inhibitor overcome by an increase in [S]? What about a noncompetitive inhibitor?
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Yes; No.
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Does a competitive inhibitor bind to the enzyme's active site? What about a noncompetitive inhibitor?
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Yes; No.
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What is a competitive inhibitor's effect on Vmax? What about a noncompetitive inhibitor's effect on Vmax?
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None; Decreases Vmax.
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What is a competitive inhibitor's effect on Km? What about a noncompetitive inhibitor's effect on Km?
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Increases Km; No effect.
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What is a competitive inhibitor's effect on overall pharmacodynamics? What about a noncompetitive inhibitor's overall effect on pharmacodynamics?
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Decreases potency; Decreases efficacy.
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What is the equation for Volume of Distribution (Vd)?
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Vd = Amount of drug in the body/plasma drug concentration.
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What is the equation for Clearance (CL)?
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CL = 0.7 x Vd / t(1/2)
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What is the equation for loading dose?
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Loading Dose = Css x Vd
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What is the equation for maintenance dose?
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Maintenance Dose = Css x CL
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What is the equation for Therapeutic Index (TI)?
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TI = LD50 / ED50
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What effect does a partial agonist have on pharmacodynamics?
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Shifts the curve down (Decreases Vmax), can either increase or decrease potency.
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What is the competitive antagonist in the case of benzo overdose?
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Flumazenil.
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What type of reactions occur during Phase I metabolism?
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Hydrolysis, oxidation, reduction.
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What type of reactions occur during Phase II metabolism?
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Glucuronidation, sulfation, acteylation.
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What are the P-450 inhibitors?
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"MAGIC RACKS": Macrolides, amiodarone, grapefruit juice, isoniazid, cimedtidine, ritonavir, acute alcohol abuse, ciprofloxacin, ketoconazole, sulfonamides.
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What are the P-450 inducers?
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"BCG QRS": Barbituates, carbamazepine, griseofulvin, quinidine, rifampin, st. john's wart. Also, chronic alcohol abuse.
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Treat acidic drug overdose with what? Treat basic drug overdose with what?
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NaHCO3 for acidic drug OD (salicylates); NH4Cl for basic drug OD (amphetamines).
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