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10 Cards in this Set
- Front
- Back
- 3rd side (hint)
Diagnosis?
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Fibrocystic Change of the Breast:
Note the combination of mutiple benign changes-fibrosis, microcysts, adenosis |
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Diagnosis?
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Cyst with apocrine change (Apocrine cyst)
How likely is this cyst to recur when compared to a simple cyst with cuboidal epithelium |
More likely to recur.
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Diagnosis (2 synonomous names)
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Blunt duct adenosis or Columnar cell change
Name the histologic criteria: |
luminal epith replaced by columnar cells with snouts. The ducts take on a more complicated pattern with branching, etc.
This is a benign entity |
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Diagnosis, please.
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Paget's disease of the nipple
What is the most common underlying malignancy in an affected breast? |
Ductal carcinoma (sometimes DCIS!)
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What are Toker cells?
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Clear cells that can appear in the nipple and may be mistaken for Paget cells.
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What are helpful stains in differentiating Paget cells from Bowen disease and Melanoma?
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Bowen disease- Keratinocyte CK+, S100-, EMA-, Her2Neu-
Melanoma: melanin+, s100+, CK- Paget: Melanin +/-, CEA +, keratinocyte CK -, S100 +/-, H2Neu + |
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Identify:
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Nipple Adenoma
Note the abrupt transition to the glandular tissue, distinct layers of myoep and epith tissue. |
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A benign nipple lesion characterized by comma-shaped tubules
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Syringomatous adenoma of the nipple
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Identify:
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Apocrine metaplasia
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Identify:
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Sclerosing Adenosis
Note the compression of the glands by the stroma but overall retention of the lobular structure and double-layered glands. What IHC can help you distinguish this from malignancy? |
Stains for the myoepithelial layer:
HMWK (CK5/6), SMA, Calponin, smooth muscle myosin heavy chain, p63 |