It is thought that the gene called SCN9A can cause congenital insensitivity to pain (“Congenital Insensitivity to Pain”). “At least 13 mutations in the SCN9A gene have been found to cause congenital insensitivity to pain,” which creates a premature ‘stop signal’ when it comes to making the NaV1.7 sodium channels (“SCN9A”). NaV1.7 sodium channels are an integral part of the pain process. They can be found in nerve cells whose jobs are to transmit signals of pain. People with congenital analgesia and congenital insensitivity to pain (with anhidrosis) can also have the inability to smell, which could be caused by the lack of good NaV1.7 channels, which are also found in nasal cavity nerve cells (“Congenital Insensitivity to Pain”). SCN9A mutations are a likely cause of several other pain disorders like erythromelalgia (episodes of pain and swelling in random parts of the body), small fiber neuropathy (severe pain episodes), and paroxysmal extreme pain disorder (severe pain episodes with flushing and occasional seizures)
It is thought that the gene called SCN9A can cause congenital insensitivity to pain (“Congenital Insensitivity to Pain”). “At least 13 mutations in the SCN9A gene have been found to cause congenital insensitivity to pain,” which creates a premature ‘stop signal’ when it comes to making the NaV1.7 sodium channels (“SCN9A”). NaV1.7 sodium channels are an integral part of the pain process. They can be found in nerve cells whose jobs are to transmit signals of pain. People with congenital analgesia and congenital insensitivity to pain (with anhidrosis) can also have the inability to smell, which could be caused by the lack of good NaV1.7 channels, which are also found in nasal cavity nerve cells (“Congenital Insensitivity to Pain”). SCN9A mutations are a likely cause of several other pain disorders like erythromelalgia (episodes of pain and swelling in random parts of the body), small fiber neuropathy (severe pain episodes), and paroxysmal extreme pain disorder (severe pain episodes with flushing and occasional seizures)