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19 Cards in this Set
- Front
- Back
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What are the indications for NO donors
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Termination or prevention of stable, unstable, or Prinzmetal angina, hypertensive emergencies, CHF
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What are the named of 1 group and 2 specific NO donors
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Nitrates
Nitroglycerin Isosorbide |
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What is the MOA of NO donors
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Endothelial independent vasodilation
NO donation activates guanidyl cyclase and creates cGMP which dephosphorylates myosin light chains |
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What are the 4 effects of NO donors?
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Decreased venous return
Decreased LV wall tension Decreased afterload Coronary artery dilation |
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What are the side effects of NO donors
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Orthostatic hypotension
Headache Reflex Tachycardia |
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What is the major contraindication of NO donors
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Sildenifil or any other ED drug. They will cause a hypotensive crisis together
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List 3 L-Type Calcium channel blockers.
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Verapamil
Diltiazem Nefedipine |
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What is the MOA of a calcium channel blocker
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Negative ionotropic and chronotropic effects
Vasodilation |
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Which Ca channel blocker has only moderate vasodilatory effects?
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Diltiazem
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What are the side effects of Verapamil and Diltiazem
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Bradycardia (CHF+Block)
Hypotension |
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What are the side effects of Nefedipine?
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Reflex tachycardia, peripheral edema, hypotension (weak cardiac effects, strong peripheral effects)
Coronary artery steal in extreme dilation |
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What is the major contraindication of Calcium channel blockers?
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CHF, their negative ionotropic effect could further compromise the myocardium
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What are the indications of B-antagonists?
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Angina
HTN Post MI Aneurysm MV Prolapse Hyperthyroidism Migraine |
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What are the indications of Calcium channel blockers?
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Angina
HTN Hypertrophic Cardiomyopathy Migraine Raynaud's Phenomonon |
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What are the 3 cardiac selective B blockers (B1)
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Metoprolol, Atenolol, Esmolol
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What are 3 non-selective B blockers?
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Propanolol, Nadolol, Timolol
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What is the MOA of B-Blockers
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Inhibition of the B receptor results in reduced cAMP levels affecting:
Reduced L-Type Ca channel opening Reduced Ca reuptake by the SR Reduced pacemaker inward current |
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What are the side effects of B-Blockers?
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Bronchospasm
Vasospasm Bradycardia CNS effects (lethargy, depression) ED |
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What are contraindications of B-Blockers?
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Asthema
Bradycardia Heart Block CHF PVD (watch diabetics, they can't tell they are hypoglycemic on them) |
