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21 Cards in this Set
- Front
- Back
List the two first generation H1 antagonists.
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Diphenhydramine
Chlorpheniramine |
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List the three second generation H1 antagonists
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Fexofenadine
Loratadine Citrizone |
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What are the contraindications of Fexofenadine?
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Glaucoma
Urinary Retention MAOI's |
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What are the contraindications of Loratadine?
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Pregnancy
Breast Feeding |
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What are two general contraindications for anti-histamines?
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COPD
Asthma |
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What is the elimination for the H1 antagonists? Approximately how long are the half lives for each generation?
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All are hepatic
1st generation: 4-6 hrs 2nd generation: 12-24 hrs |
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What are the side effects of H1 blockers?
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Anorexia
Nausea/Vomiting Blood dyscarias |
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What is the advantage of the second generation H1 antagonists?
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They don not cross the BBB and therefore done cause the same fatigue.
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What is Doxepin
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A tricyclic antidepressant. It has very strong H1 blocking effects too.
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What are the indications for the H2 antagonists?
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Ulcers
GERD Prevention of esophageal bleeding |
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List 4 H2 antagonists.
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Cimetidine
Ranitidine Famotidine Nizatidine |
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What are contraindications of H2 antagonists?
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Not much really.
Gynecomastia in a small number of men. Reduce doses with liver/renal patients |
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What are some of the effects of histamine?
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Dilitation of the afferent arterioles
Hypotension Increased intercellular space Gastric Secretion Bronchoconstriction |
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List 5 PPI's
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Omeprazole
Lansoprazole Pantoprazole Rabeprazole Esomepraxole |
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What are the indications for PPI's
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Gastric Ulcers
GERD (secondary to H2 blockers) Treatment of H. Pylori |
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What are the contraindications for PPI's
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H2 antagonists
Benzodiazpines Warfarin Phenytoin |
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What is the MOA of PPI's
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Irreversibly inhibit H/K ATPases. The drugs are prodrugs activated in an acidic environment
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What are the side effects of PPI's?
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Myalgia
Diarrhea, headache, constipation |
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What are the indications of sucralate?
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Duodinal ulcers, it is a mucosal coating agent.
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What are the contraindications of sucralfate?
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H2 blockers
Floroquiniliones Digoxin Grapefruit (absorbs Al in compound) |
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What is the treatment of H. Pylori ulcers?
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2 of 3 Antibiotics: Metronidazole, Claritromicin, Amoxicillin (1 week)
-or- PPI + 1 antibiotic (2 weeks) |