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15 Cards in this Set
- Front
- Back
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Components of Blood |
Plasma and Cellular Elements |
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Plasma |
Composed of: Water Ions Organic molecules (AA, Proteins, glucose, lipids, and N2 wastes) Trace elements and vitamins Gases (CO2 and O2) |
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Plasma Proteins |
Albumins: contributor to osmotic pressure Globulins: clotting factors, enzymes, antibodies Fibrinogens: form fibrin thread for clotting Transferrin: Fe transport all from liver |
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Cellular Elements of Blood |
RBCs: erythrocytes WBCs: leukocytes - Lymphocytes, Monocytes, Neutrophils, Eosinophils, Basophils Platelets: split from megakaryocytes |
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Hematopoiesis |
Formation of blood |
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Hemocytoblasts |
Blood stem cells |
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White Blood Cells |
Leukocytes Lymphocytes: immunocytesMonocytes: devo into macrophages in tissue Neutrophils: phagocyte Eosinophils: allergy and parasite response Basophils: mast cells, inflam response Abundance: (Never Let Monkeys Eat Bananas) |
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Red Blood Cell |
Most abundant in blood (5mill / 1uL) Facilitate O2/CO2 transport to/from cells Biconcave disc (increase surface area) Non nucleated Flexible and compressible Complex cytoskeleton to transport proteins 120 day life span |
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Hemoglobin |
Main component of RBC Protein molecule with 4 heme grps Binds to O2 Requires Fe for synthesis. |
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Iron Homeostasis and Metabolism |
1. Fe in diet 2. Fe absorbed in sml intestine 3. Transferrin transports Fe to plasma (liver stores excess) 4. Bone marrow uses Fe to make Hb for RBC synthesis 5. Old RBCs destroyed in spleen. Hb to bilirubin 6. Bilirubin excreted in feces 7. Or liver metabolizes and excretes in bile |
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Functions of Spleen |
Composed of: - red pulp (recycling of RBCS) - Hb decomposed to bilirubin and excreted by kidney or metabolized in liver and excreted as bile. - white pulp (recycling of WBCs and storage) |
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Damaged Blood Vessel |
Cut exposes collagen in damaged wall. Signals platelets -> vasoconstriction More platelets arrive Platelet plug forms Thrombin converts fibrinogen to fibrin and clot forms |
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Chemicals Involved in Clotting Process |
Collagen: injury exposes; platelets bind (plug) von Willebrand factor: collagen exposure; platelets bind to collagen Serotonin: plate activation; plate aggregation ADP: plate activation; plate aggregation Platelet activating factor: plate activation; plate aggregation Thromboxane: plate activ factor; plate aggreg Platelet Derived GF: plate activation |
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Chemicals Involved in Coagulation |
Plasminogen/Plasmin: dissolves fibrin Tissue Plasminogen Activator: activates plasminogen Antithrombin III: anticoagulant Prostacyclin: blocks platelet aggregation |
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Coagulation and Fibrinolysis |
1) Coagulation - Thrombin converts Fibrinogen to fibrin 2) Clot - formed by fibrin 3) Fibrinolysis - Plasminogen + thrombin + tissue plasminogen activator = plasmin - plasmin dissolves fibrin into fragments |
